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多发性骨髓瘤是异常浆细胞的单一无性系增生为特征的一种肿瘤。在60和70岁人中多见,诊断时平均年龄62岁,较多见于男性。最常见到的症状是骨骼疼痛和虚弱,X线照片显示典型的凿孔状溶骨性损害,同时也可见到遍及全身的骨质疏松。发生病理性骨折者占20%。疾病进行时常伴有高血钙、高尿酸尿、肾脏损害。骨髓置换导致患者贫血,血小板减少、中性白细胞减少。由于正常免疫功能受到抑制,机体对感染的敏感性增加。口腔表现常是这种疾病的初期体征,检查常发现有疼痛、肿胀、麻木、牙松动和软组织肿瘤。颌骨X线照片显示多数透射区、
Multiple myeloma is a tumor characterized by a single clonal proliferation of abnormal plasma cells. Prevalent in 60 and 70 years of age, the average age at diagnosis of 62 years old, more common in men. The most common symptoms are bone pain and weakness. X-rays show typical perforation-like osteolytic lesions and osteoporosis throughout the body. Pathological fractures accounted for 20%. Often accompanied by high blood calcium disease, high urine uric acid, kidney damage. Bone marrow replacement leads to anemia in patients with thrombocytopenia and neutropenia. As the normal immune function is suppressed, the body's sensitivity to infection increases. Oral manifestations are often the initial signs of this disease, often found in pain, swelling, numbness, tooth mobility and soft tissue tumors. Jaw radiographs show most of the transmissive area,