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目的 :观察环孢素A治疗难治性狼疮性肾炎的疗效。方法 :采用环孢素A(田可 ) 0 .5mg/kg/d治疗 30例难治性狼疮性肾炎 ,疗程 12周。治疗前、后观察患者临床表现 ;尿蛋白定量 ;肾功能及血清C3、C4 、T细胞亚群等指标。结果 :环孢素A治疗 12周后 ,患者临床症状明显改善 ,尿蛋白减少 ,肾功能改善 ,血清C3、C4 、T细胞亚群与治疗前比较均有显著性差异。结论 :环孢素A对难治性狼疮性肾炎治疗有效 ,但其远期疗效还有待于进一步研究
Objective: To observe the curative effect of cyclosporin A on refractory lupus nephritis. Methods: Cyclosporine A (Tian Ke) 0 .5mg / kg / d treatment of 30 cases of refractory lupus nephritis, the course of 12 weeks. Before and after treatment, clinical manifestations were observed; urinary protein quantitation; renal function and serum C3, C4, T cell subsets and other indicators. Results: After 12 weeks of treatment with cyclosporin A, clinical symptoms were significantly improved, urinary protein decreased, renal function improved, serum C3, C4, T cell subsets were significantly different from before treatment. Conclusion: Cyclosporine A is effective in the treatment of refractory lupus nephritis, but its long-term efficacy remains to be further studied