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美国佐治亚大学兽医学院的226名工作人员和学生在加强接种0.1ml(皮内)人二倍体细胞狂犬病疫苗(HDCV)后,发生23例(10.2%)免疫复合物样疾病。他们曾在两年前接受过3针HDCV全程免疫。23例患者于接种后3～13天出现症状和体征,主要表现为全身性荨麻疹(78.3%)、躯干、臂和腿部的斑丘疹(65.2%)、面部(尤其口唇)、手和足的血管神经性水肿(39.1%)及关节疼痛(17.4%)。有1例除水肿和荨麻疹外,还伴有一过性呼吸困难;另1例除水肿、荨麻疹和关节疼痛外,还伴有发热和不适。21例经抗组胺药或皮质类固醇治疗,2例未经治疗,所有病例的症状持续1～5天。经观察无严重
Twenty-two (10.2%) immunocomplex-like diseases occurred in 226 staff and students at the University of Georgia College of Veterinary Medicine after intensive vaccination with 0.1 ml (intradermal) human diploid cell rabies vaccine (HDCV). They received 3-needle HDCV full immunization two years ago. Twenty-three patients developed symptoms and signs 3 to 13 days after inoculation. The main symptoms were systemic urticaria (78.3%), maculopapular rash on the trunk, arms and legs (65.2%), facial features (especially the lips), hands and feet Of angioneurotic edema (39.1%) and joint pain (17.4%). In addition to 1 case of edema and urticaria, accompanied by transient dyspnea; the other one in addition to edema, urticaria and joint pain, but also accompanied by fever and discomfort. Twenty-one patients were treated with antihistamines or corticosteroids, and two were untreated, and symptoms were sustained in all cases for 1 to 5 days. No serious observation