探讨病证结合脾肾阳虚腹泻型肠易激综合征大鼠模型的建立和评价方法。认为可采用较为公认的母婴分离、直肠扩张、避水应激等方法建立疾病模型,同时以饮食不节、苦寒泻下结合劳倦过度、惊恐伤肾的复合因素复制中医脾肾阳虚证模型;模型评价可从宏观体征、个别理化指标、药物反证和造模因素反推4个维度进行,使得相关模型更符合中医理论。 To investigate the establishment and evaluation of the rat model of diarrhea-predominant irritable bowel syndrome with syndrome of deficiency of spleen and kidney. It is considered that the disease model can be established by the more commonly recognized method of separation of maternal and infant, rectum dilation and avoidance of water stress. At the same time, the model of TCM of spleen-kidney-yang deficiency syndrome is duplicated with the combination of excessive diet, bitter cold and diarrhea, The model evaluation can be carried out in four dimensions of macro-physical signs, individual physical and chemical indicators, drug evidences and modeling factors, which makes the correlation model more in line with traditional Chinese medicine theory.