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目的探讨进驻不同海拔高度居住不同时间的健康青年血管内皮生长因子 (VEGF)的变化。方法对从平原进驻海拔 3 70 0m和 53 80m高原第 7天及半年的 40名某部官兵 ,运用双抗体夹心酶联免疫法(ELISA)检测其血清VEGF的含量 ,并与 2 0名平原健康青年作对照。结果进驻高原低氧环境 ,被试者VEGF含量明显高于平原对照组 (P <0 .0 5或P <0 .0 0 1 ) ,且随海拔高度的升高而增高非常显著 ,随居住高原时间的延长而降低显著 (P <0 .0 0 1 )。结论高原低氧环境血清VEGF的含量明显升高 ,可能在低氧性肺动脉高压的发生过程中发挥了重要作用。
Objective To investigate the changes of vascular endothelial growth factor (VEGF) in healthy young people living in different altitudes at different altitudes. Methods Forty soldiers from a certain department which were stationed at 3 700 m and 53 80 m above sea level on the 7th day and half a year in the plains were tested for serum VEGF levels by sandwich enzyme-linked immunosorbent assay (ELISA) Youth as a control. Results In the plateau hypoxia environment, the content of VEGF in the subjects was significantly higher than that in the plain control group (P <0.05 or P <0.01), and increased significantly with altitude, The decrease of time was significant (P <0. 001). Conclusion The serum level of VEGF in plateau hypoxia environment is significantly increased, which may play an important role in the pathogenesis of hypoxic pulmonary hypertension.