论文部分内容阅读
目的探讨阿加曲班治疗急性脑梗死的临床疗效。方法回顾分析120例急性脑梗死患者,阿加曲班治疗组(60例)和对照组(60例)。治疗组予静脉滴注阿加曲班,开始的48h内,60mg/24h加入500ml生理盐水持续泵入,后改为10mg加入100ml生理盐水持续3h以上滴入,2次/d,再连用5d,后改为阿司匹林0.1,日一次口服。联合依达拉奉30mg加入100ml生理盐水,30min内滴完,2次/d;活血化瘀作用的中药;调脂、降糖、降压等药物。对照组不用阿加曲班,应用阿司匹林0.1,1次/d,余治疗同治疗组。分别在治疗前、治疗后10d进行NIHSS评分,测定血常规、凝血象。并观察治疗期间不良反应。结果治疗组神经系统功能恢复和对照组相比有显著差异,未见出血病例。结论阿加曲班治疗急性脑梗死安全有效。
Objective To investigate the clinical efficacy of argatroban in the treatment of acute cerebral infarction. Methods A retrospective analysis of 120 patients with acute cerebral infarction, argatroban treatment group (60 cases) and control group (60 cases). The treatment group was given intravenous argatroban, the first 48h, 60mg / 24h added 500ml saline continued pumped, then changed to 10mg added 100ml saline for 3h or more, 2 times / d, then use 5d, After the change to aspirin 0.1, once daily oral. Combined edaravone 30mg added 100ml saline, drip finished within 30min, 2 times / d; Chinese medicine to promote blood circulation; lipid-lowering, hypoglycemic, antihypertensive and other drugs. The control group without argatroban, aspirin 0.1,1 / d, Yu treatment with the treatment group. NIHSS scores were measured before treatment and 10 days after treatment respectively, and blood routine and coagulation were measured. And observed during treatment of adverse reactions. Results The recovery of nervous system in the treatment group was significantly different from that in the control group, and no bleeding was found. Conclusion Argatroban is safe and effective in the treatment of acute cerebral infarction.