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人体对人类免疫缺陷病毒(HIV)的易感性及病理过程明显不同,为探讨不同遗传学背景的宿主单核细胞对其中HIV复制的影响,作者用孪生子和无关献血员的单核细胞对HIV-1分离株的复制动力学进行了比较。分别采集7对同卵孪生子(ID)、2对异卵孪生子(NID)和12对性别相同及年龄可比的无关献血员(URD)的单核细胞,进行细胞培养,并用3个不同的HIV-1临床分离
Human susceptibility to human immunodeficiency virus (HIV) and pathological processes were significantly different, in order to explore the different genetic backgrounds of host monocytes in which HIV replication, the author of twins and unrelated donor monocytes of HIV -1 isolates were compared for their replication kinetics. Seven pairs of identical twins (ID), two pairs of fraternal twins (NIDs), and twelve pairs of sexually-identical and age-matched unrelated blood donors (URDs) were collected for cell culture and cultured with three different HIV-1 clinical isolation