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目的:研究帕金森病(PD)患者双侧丘脑和双侧基底节区磁共振扩散张量成像(DTI)的变化,评价DTI技术用于早期PD的诊断价值。方法 :以PD患者26例为PD组,按Hoehn-Yahr分级量表将患者分为PD组1和PD组2;健康志愿者26例为对照组;常规行MR头部平扫和DTI检查,比较双侧丘脑、基底节区的部分各向异常分数(FA)值和表观弥散系数(ADC)值。结果:PD组尾状核和丘脑的部分各向异常分数FA值明显低于对照组(P<0.05),PD组兴趣区的ADC值在各组之间、病变双侧之间和对照组之间无明显差异(P>0.05),但随着病情级别的增加,ADC值呈增高趋势。结论:磁共振DTI的尾状核、丘脑的FA值有助于PD的早期诊断。
Objective: To study the changes of magnetic resonance diffusion tensor imaging (DTI) in bilateral thalamus and bilateral basal ganglia in patients with Parkinson’s disease (PD) and evaluate the diagnostic value of DTI in early PD. Methods: Twenty-six patients with PD were selected as PD group. According to the Hoehn-Yahr grading scale, patients were divided into two groups: PD group 1 and PD group 2; healthy volunteers 26 as control group; routine MR plain MR imaging and DTI examination, Bilateral thalamus and basal ganglia were compared for partial anisotropy (FA) values and apparent diffusion coefficient (ADC) values. Results: The FA values of the part of anisotropy in caudate nucleus and thalamus in PD group were significantly lower than those in control group (P <0.05). The ADC value of interest area in PD group was significantly higher than that in control group There was no significant difference between the two groups (P> 0.05). However, the ADC value increased with the increase of disease severity. Conclusion: The values of FA in the caudate nucleus and thalamus of magnetic resonance DTI contribute to the early diagnosis of PD.