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取代苯甲醛与盐酸羟胺反应生成取代苯甲醛肟,经氯代得到相应的氯代苯甲醛肟,再和N-乙烯基吡咯烷酮、2-乙烯基吡啶、4-乙烯基吡啶等进行1,3-偶极环加成反应,合成了15个未见报道的异噁唑啉类化合物.其结构经过1H NMR,13C NMR及高分辨质谱表征.初步的生物活性测试结果表明,目标化合物3b对黄瓜灰霉表现出了很好的防效,化合物3c对番茄早疫、花生褐斑和油菜菌核表现出了很好的防效,化合物3e~3o对花生褐斑、苹果轮纹、番茄早疫、小麦赤霉、辣椒疫霉、油菜菌核、水稻纹枯等7种真菌具有很好的防效,表现出了广谱的抑菌活性.
The substituted benzaldehyde and hydroxylamine hydrochloride react to form the substituted benzaldoxime, the corresponding chlorobenzaldoxime is obtained through chlorination, and then 1,3-benzodiazepine is reacted with N-vinylpyrrolidone, 2-vinylpyridine, 4- 15 unidentified isoxazoline compounds were synthesized and their structures were characterized by 1H NMR, 13C NMR and high resolution mass spectrometry.The preliminary bioassay results showed that the target compound 3b could effectively inhibit the growth of cucumber ash The results showed that compound 3c showed a good control effect on early weeping tomato, peanut brown spot and sclerotia of tomato. Compound 3e ~ 3o had good effect on peanut brown spot, apple leaf pattern, early maturing tomato, Seven kinds of fungi, such as Gibberella zeae, Phytophthora capsici, Sclerotinia sclerotiorum and Rhizoctonia solani, had good antifungal effect and showed a broad spectrum of antibacterial activity.