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目的探讨载脂蛋白E与抗精神病药致脂代谢紊乱的关系。方法测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL),采用双抗体酶联免疫吸附法测定载脂蛋白E浓度,测量身高和体质量,采用聚合酶链扩增技术(PCR)和限制性片段长度多态性技术测定载脂蛋白E(APOE)基因多态性。结果 (1)在药物治疗前,研究组与健康对照组对比,体质量、载脂蛋白E浓度及血脂各项指标差异无统计学意义(P>0.05);(2)研究组BMI、TG、LDL和TC治疗后较治疗前均显著增加,差异有统计学意义(P<0.01,P<0.05),HDL和APOE血清浓度则无显著变化(P>0.05);(3)在治疗后,E4/X基因型者BMI、TC和TG、LDL较治疗前均显著升高(P<0.01,P<0.05)。结论载脂蛋白Eε4基因是抗精神病药物所致脂代谢紊乱的危险因素。
Objective To investigate the relationship between apolipoprotein E and antipsychotic disorder caused by lipid metabolism. Methods Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) were measured. The apolipoprotein E concentration was measured by double antibody enzyme linked immunosorbent assay The APOE gene polymorphism was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results (1) There was no significant difference in body weight, apolipoprotein E concentration and blood lipids between study group and healthy control group before treatment (P> 0.05). (2) The BMI, TG, (P <0.01, P <0.05), serum HDL and APOE levels did not change significantly (P> 0.05); (3) After treatment, E4 / X genotype BMI, TC and TG, LDL were significantly higher than before treatment (P <0.01, P <0.05). Conclusion The apolipoprotein Eε4 gene is a risk factor for the disorder of lipid metabolism induced by antipsychotics.