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【目的】探讨孤独症患儿感觉门控P50的特征,以期为孤独症的早期诊断找到脑电生理的相关依据。【方法】应用美国Nicolet Bravo脑电生理仪,采用条件刺激(S1)-测试刺激(S2)模式对39名孤独症患儿及31名正常儿童进行感觉门控P50的检测,分析孤独症患儿感觉门控P50的特征。采用SPSS11.0软件包进行统计。【结果】1)孤独症患儿对条件刺激的反应波幅(S1-P50)与对测试刺激的反应波幅(S2-P50)之间差异无统计学意义;2)孤独症患儿感觉门控P50:S1-P50波幅、S2-P50波幅及S2/S1、S1-S21、00(1-S2/S1),在3个脑区差异无统计学意义;3)孤独症患儿对声音刺激的潜伏期较长;4)孤独症患儿听觉P50抑制明显减弱;S1-P50波幅健康对照组为(5.71±3.75)μV,孤独症组为(4.09±2.42)μV(P<0.05);S2-P50波幅健康对照组为(2.71±2.29)μV,孤独症组为(4.47±3.02)μV(P<0.01);波幅S1-S2的差值健康对照组为(3.00±3.52)μV,孤独症组为(-0.38±2.41)μV(P<0.01)。【结论】孤独症患儿的感觉门控P50明显受损;孤独症患儿对声音刺激的加工速度较慢。
【Objective】 To explore the characteristics of sensory gating P50 in children with autism, with a view to finding relevant evidences of brain electrophysiology for the early diagnosis of autism. 【Methods】 Sensory gating P50 was detected in 39 children with autism and 31 normal children by conditioned stimulation (S1) -test stimulus (S2) mode using American Nicolet Bravo electroencephalography apparatus. The autistic children Feel gated P50 features. SPSS11.0 software package for statistics. 【Results】 1) There was no significant difference in response amplitude (S1-P50) and response amplitude (S2-P50) between children with autism and conditioned stimulus; 2) Sensory gating P50 : S1-P50 amplitude, S2-P50 amplitude and S2 / S1, S1-S21,00 (1-S2 / S1), no significant difference in the three brain regions; 3) children with autism of the stimulation of the sound of the incubation period (P <0.05). The amplitude of S2-P50 in control group was (5.71 ± 3.75) μV for S1-P50 amplitude and (4.09 ± 2.42 μV) in autism group (2.71 ± 2.29) μV in the healthy control group and (4.47 ± 3.02) μV in the autism group (P <0.01). The differences of the amplitude S1-S2 in the healthy control group were (3.00 ± 3.52) μV, -0.38 ± 2.41) μV (P <0.01). 【Conclusion】 Sensory gating P50 in children with autism is significantly impaired; children with autism have a slower pace of sound stimulation.