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作者研究了患何杰金病(HD)曾用联合化疗的妇女的性功能障碍的发病率及其严重程度。 44例治疗时的中位年龄为23(13～45)岁,均处于临床缓解。自化疗结束至研究历时6个月～10年(中位数30个月)。其中37例用MVPP方案:氮芥6mg/M~2(最大剂量10mg)第1天,长春花碱6mg/M~2第1和第8天,甲基苄肼150mg/d第1～14天,强的松40mg/d第1～14天,6周为1疗程。4例用苯丁酸氮芥(CLB)15mg/d第1～14天,替代氮芥。另2例用数疗程MVPP后因不能耐受氮芥而改为
The authors studied the incidence and severity of sexual dysfunction in women who had previously received combined chemotherapy for Hodgkin’s disease (HD). The median age of 44 patients was 23 (13-45) years old, all of whom were in clinical remission. From the end of chemotherapy to study lasted from 6 months to 10 years (median 30 months). 37 of them were treated with MVPP regimen: nitrogen mustard 6mg / M ~ 2 (maximum dose 10mg) on day 1, vinblastine 6mg / M ~ 2 on days 1 and 8, procarbazine 150mg / d on days 1 to 14 , Prednisone 40mg / d 1 to 14 days, 6 weeks for a course of treatment. 4 cases with chlorambucil (CLB) 15mg / d 1 to 14 days, instead of nitrogen mustards. The other two cases with a few MVVC after treatment due to not tolerate nitrogen mustard instead