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目的:研究IFITM1蛋白在新疆维吾尔族妇女子宫颈鳞癌组织中的表达及临床意义。方法:应用实时定量逆转录PCR方法检测15例维吾尔族妇女子宫颈鳞癌及其癌旁子宫颈正常组织中IFITM1基因mRNA表达水平。结果:15例子宫颈癌组织中IFITM1的mRNA表达丰度为(64.79±42.71)%,正常宫颈组织中IFIM1的mRNA的表达丰度为(128.29±88.77)%,正常宫颈组织表达丰度显著高于子宫颈癌组织(t=-2.497,P=0.09)。新疆维吾尔族妇女慢性子宫颈炎与子宫颈鳞癌组织中IFITM1基因mRNA的表达具有统计学差异(P<0.05)。结论:IFITM1蛋白与新疆维吾尔族妇女的子宫颈鳞癌有着密切的关系,该基因可能是一种潜在的抑制子宫颈鳞癌发生的基因。
Objective: To study the expression and clinical significance of IFITM1 protein in cervical squamous cell carcinoma of Uighur women in Xinjiang. Methods: Real-time quantitative RT-PCR was used to detect the mRNA expression of IFITM1 in cervical squamous cell carcinoma and normal cervical tissues of 15 Uighur women. Results: The mRNA abundance of IFITM1 was (64.79 ± 42.71)% in 15 cases of cervical cancer tissues, and (128.29 ± 88.77)% in normal cervical tissues. The expression level of IFIT1 mRNA in normal cervical tissues was significantly higher than that of normal cervical tissues Cervical cancer tissue (t = -2.497, P = 0.09). The expression of IFITM1 mRNA in chronic cervicitis and cervical squamous cell carcinoma of Xinjiang Uygur women was statistically different (P <0.05). CONCLUSION: IFITM1 protein is closely related to cervical squamous cell carcinoma in Xinjiang Uygur women, which may be a potential gene that inhibits the occurrence of cervical squamous cell carcinoma.