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脑动脉血管痉挛是颅内动脉瘤破裂、SAH 患者发病和死亡的主要原因。至今,血管痉挛的病理机制仍不清楚。本研究的目的是测定 SAH 患者基底动脉血管反应性的变化。基底动脉取自 SAH 后1日内死亡者(SAH 组),及非脑病变而死亡2～10h 内的尸体(对照组)。将基底动脉悬于 Krebs-Ringer 液中除去血凝块及蛛网膜。然后分割成2～3条2mm 宽、15mm 长的标本垂直挂在上下两个钩上,浸于37℃、pH7.4的 Krebs-Ringer液中,通以95%O_2及5%CO_2混合气体作收缩或舒
Cerebral arterial vasospasm is a leading cause of ruptured intracranial aneurysms and morbidity and mortality in SAH patients. So far, the pathological mechanism of vasospasm remains unclear. The purpose of this study was to determine changes in basilar vascular reactivity in patients with SAH. Basal arteries were killed within 1 day after SAH (SAH group), and non-brain lesions within 2 ~ 10h of death (control group). The basilar artery was suspended in Krebs-Ringer’s solution to remove blood clots and arachnoid. Then, the specimens were divided into 2 to 3 specimens of 2 mm in width and 15 mm in length. The specimens were vertically hung on the upper and lower hooks and immersed in a Krebs-Ringer solution at 37 ° C and pH 7.4, mixed with 95% O 2 and 5% CO 2 gas Shrink or Shu