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CD27是由跨膜二硫键连接的55KD二聚体,在大部分外周血T细胞和部分B细胞上表达。TCR/CD3复合物激活T细胞后,使细胞膜表面CD27的表达增加,同时释放出32KD可溶性部分(sCD27)。 作者对sCD27作为淋巴系统恶性肿瘤脑膜浸润的肿瘤标志在诊断学方面的价值进行了前瞻性研究。采用夹心ELISA法检测CSF中sCD27水平。初次CSF细胞学检查阳性或初检阴性,但临床有明确脑膜浸润表现,而1月后检查阳性者为CSF肿瘤阳性标本。经统计学处理CSFsCD27阳性标准为>10u/ml。
CD27 is a 55KD dimer linked by a transmembrane disulfide bond and is expressed on most peripheral blood T cells and part of B cells. Activation of T cells by the TCR / CD3 complex increased the expression of CD27 on the cell membrane surface while releasing a 32 KD soluble fraction (sCD27). The authors prospectively evaluated the diagnostic value of sCD27 as a tumor marker of meningeal invasion of lymphoid malignancies. Sandwich ELISA was used to detect CSF sCD27 levels. Initial CSF cytology positive or negative initial examination, but the clinical manifestations of meningeal clear, but after January to check positive for CSF tumor-positive specimens. The statistical treatment of CSFsCD27 positive standard> 10u / ml.