内皮素(ET)是由血管内皮细胞释放的一组具有强烈血管收缩作用的内源性物质,一氧化氮(NO)是体内重要的舒血管活性物质,二者共同调节着血管的舒缩。近来的研究发现,二者可能参与了糖尿病(DM)血管并发症的发生与发展。本研究测定了81例Ⅱ型DM患者血浆ET、NO的稳定代谢产物NO_2~-水平及二者比值,并与30名正常人进行对照,现报告如下。 对象和方法 1.对象 1997.10—1998.7本院内科门诊治疗的 Endothelin (ET) is a group of endogenous substances released by vascular endothelial cells and has a vasoconstrictive effect. Nitric oxide (NO) is an important vasodilator in the body, and both regulate the contraction and contraction of blood vessels. Recent studies have found that both may be involved in the occurrence and development of diabetic vascular complications. This study measured 81 patients with type II DM plasma ET, NO metabolites NO 2 - level and the ratio between the two, and 30 normal controls, are as follows. Subjects and methods 1. Object 1997.10-1998.7 hospital medical out-patient treatment