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目的探讨使用美兰染料法示踪和定位乳腺癌前哨淋巴结(SLN)的可行性和预测乳腺癌腋窝淋巴结(ALN)转移的准确性。方法对66例临床0～Ⅱ期乳腺癌患者在乳晕下及肿瘤周围皮下注射国产蓝色染料亚甲蓝示踪和定位前哨淋巴结,行前哨淋巴结活检并腋窝淋巴结清扫,对全部的前哨淋巴结和腋窝淋巴结行病理检查并分析结果。结果66例中成功检出前哨淋巴结62例,检出率93.9%(62/66);SLN对ALN状况预测的灵敏度为85.5%(53/62);准确性为91.9%(57/62);假阴性率为12.2%(5/41);假阳性率为0(0/41)。结论使用国产染料亚甲蓝示踪和定位乳腺癌前哨淋巴结是可行的,在乳腺癌中有良好的成功率,能较准确地预测腋窝淋巴结的情况。
Objective To investigate the feasibility of using the Mulan dye method to track and locate sentinel lymph node (SLN) in breast cancer and to predict the accuracy of axillary lymph node metastasis (ALN) in breast cancer. Methods Sixty-six patients with clinical stage 0 ~ Ⅱ breast cancer were subcutaneously injected methylene blue under the areola and the tumor around the tumor, and the sentinel lymph node was located. The sentinel lymph node biopsy and axillary lymph node dissection were performed. All sentinel lymph nodes and axillary Lymph pathological examination and analysis of the results. Results Sixty - six cases of sentinel lymph node were successfully detected, the detection rate was 93.9% (62/66). The sensitivity of SLN to predicting ALN was 85.5% (53/62) and the accuracy was 91.9% (57/62). The false negative rate was 12.2% (5/41); the false positive rate was 0 (0/41). Conclusion It is feasible to use the domestic dye methylene blue to track and locate sentinel lymph node in breast cancer. It has a good success rate in breast cancer and can predict axillary lymph node more accurately.