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目的 :探讨妊娠相关蛋白A(PAPP -A)作为血清标记物在孕早期产前筛查中应用的价值。方法 :用酶联免疫吸附法 (ELISA)测定孕 9～ 1 3周孕妇血清中PAPP -A浓度。结果 :共检测 2 70 1例 9～ 1 3周单胎妊娠孕妇 ,筛查出PAPP -A低值的高危孕妇 1 6 0例 ,确诊染色体异常 (2 1三体 ) 2例 ,高危组不良妊娠结局 8例 ,筛查高危组与筛查正常组不良妊娠结局比较有显著差异 (x2 =4 3 38,p <0 0 1 )。结论 :PAPP -A可作为孕早期染色体异常 (2 1三体 )筛查的一个指标 ,对于PAPP -A低值的孕妇提示有不良妊娠结局的可能
Objective: To investigate the value of pregnancy-associated protein A (PAPP-A) as a serum marker in early pregnancy prenatal screening. Methods: The concentration of PAPP-A in sera from 9 to 13 weeks pregnant women was determined by enzyme-linked immunosorbent assay (ELISA). Results: A total of 2 701 pregnant women with 9 ~ 13 weeks of singleton pregnancy were screened. Among them, 160 cases of high PAPP-A low risk pregnant women were screened out, 2 cases of chromosomal abnormalities (2 1 trisomy) and 2 cases of poor pregnancy There were significant differences in 8 cases between the high-risk screening group and the normal screening group (x2 = 4338, p <0.01). Conclusions: PAPP-A can be used as an indicator of chromosomal abnormality (trisomy 21) screening in early trimester, suggesting the possibility of adverse pregnancy outcome in pregnant women with low PAPP-A