苯二氮类药物自1957年问世以来发展较快,目前常用约有安定、三唑安定、去甲羟基安定、氯羟安定、氟安定、氯硝安定及阿普唑仑等。兹将这类药物的代谢动力学及药物间的相互作用、介绍于下。一、苯二氮革类的药代动力学这些药物有较高的脂溶性,进入血流后,迅速透过血脑屏障进入中枢神经系统而发挥作用~((1))。催眠作用的持续时间与药物在体内的分布与药物脂溶性有关~((2))。安定和氯羟安定均能迅速进入中枢神经系统抑制癫痫发 Benzodiazepines have developed rapidly since their introduction in 1957. At present, diazepam, triazolam, norczolac, chlorhexidine, diazepam, clonazepam and alprazolam are commonly used. The pharmacokinetics and drug-drug interactions of these drugs are described below. First, benzodiazepine pharmacokinetics These drugs have a higher fat-soluble, into the bloodstream, quickly through the blood-brain barrier into the central nervous system and play a role ~ ((1)). The duration of the hypnotic effect is related to the drug’s in vivo distribution and drug-lipid solubility (2). Both diazepam and chlorhexidine can rapidly enter the central nervous system to suppress epilepsy