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目的 探讨肠道线虫病低度流行区的防治措施。 方法 自 1 995年根据流行区人群肠道线虫感染的年龄及临床症状等流行病学特点 ,在江苏省江都市吴堡乡 3个试点村中 ,每年每村选择 2 0 0人左右作为高危人群采取目标化疗 ,以阿苯达唑和甲苯达唑各 2 0 0mg顿服 ,每年 1次连续 3年。次年化疗前在村民中抽样粪检 1次 ,末次治疗 3年后再复查 1次。以饱和盐水漂浮法和定量透明法粪检结果评价疗效。 结果 3个试点村居民肠道线虫感染率由1 995年的 6 .2 %降至 1 996年的 5 .4 %和 1 997年的 3 .2 % ,2 0 0 0年复查感染率为 2 .3 %。对照村仅对小学生化疗每年 1次连续 5年 ,蛔虫和鞭虫的感染率分别由 1 995年的 1 .4 %和 4 .2 %降至 2 0 0 0年的 0 .9%和 1 .4 % ,钩虫感染率下降不明显。钩虫易感人群的目标化疗结果表明 ,41岁以上人群感染率由 1 995年的 1 9.4 %降至 2 0 0 0年的 1 0 .9%。 结论 在肠道线虫低度流行区 ,目标化疗是一种较经济有效的防治措施
Objective To investigate the prevention and treatment of intestinal nematode disease in the endemic areas. Methods From 1995 to 1998, according to the epidemiological characteristics of intestinal nematode infection in endemic areas and the clinical symptoms, among 3 pilot villages in Wubao Township, Jiangdu City, Jiangsu Province, about 200 people were selected in each village as the high-risk population To take targeted chemotherapy to albendazole and mebendazole each 200 mg Dayton, once a year for 3 consecutive years. Next year before the chemotherapy in the villagers sampling fecal seizure 1, 3 times after the last treatment review again. Saturated saline floating method and quantitative and transparent fecal test results to evaluate the efficacy. Results The intestinal nematode infection rate of residents in three pilot villages dropped from 6.2% in 1995 to 5.4% in 1996 and 3.2% in 1997, and the infection rate in 2000 was 2 .3%. The control villages only treated primary school students once a year for 5 consecutive years. The infection rates of roundworms and whipworms decreased from 1.4% and 4.2% in 1995 to 0.9% and 1 in 2000, respectively. 4%, hookworm infection rate decreased not obvious. Targeted chemotherapy in susceptible populations of hookworms showed that the prevalence of infection among people over the age of 41 decreased from 9.45% in 1995 to 1.09% in 2000. Conclusion In the low endemic area of intestinal nematodes, targeted chemotherapy is a more economical and effective control measures