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代谢研究已提示,丙烯腈在哺乳动物体内可经微粒体混合功能氧化酶的作用氧化为不稳定的中间体环氧丙烯腈,这是一个具有潜在致突变和致癌活性的化学物,是丙烯腈引起慢性毒害作用的一个重要环节。而这二方面的不良作用,近年来已为许多实验及一些流行病学调查所证实。
Metabolic studies have suggested that acrylonitrile can be oxidized by the action of microsomal mixed functional oxidases in mammals to an unstable intermediate epoxy acrylonitrile, a potentially mutagenic and carcinogenic chemical, Chronic toxicity caused by an important part. The adverse effects of these two aspects have been confirmed by many experiments and some epidemiological investigations in recent years.