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目的:比较尤靖安、膦甲酸钠及二者联合治疗HPV感染的临床疗效,探析HPV感染临床治疗的理想方案。方法:选取我院门诊2014年1月~2016年8月共收治的96例HPV感染患者作为研究对象,按随机数字表将入选患者分为A、B、C三组,各32例。A组采取尤靖安(重组人干扰素α2b凝胶)进行治疗,B组采取单纯膦甲酸钠氯化钠注射液进行治疗,C组采用尤靖安与膦甲酸钠氯化钠注射液联合治疗。比较三组治疗前后宫颈炎指标评分、HPV转阴率及治疗总有效率。结果:三组治疗前宫颈炎指标评分的两两比较均无统计学意义;治疗后A、B、C组的宫颈炎指标评分分别降低至(2.5±0.6)分、(2.7±0.7)分、(1.1±0.4)分,与治疗前比较有统计学意义;同时C组评分低于A组与B组,A组与B组之间则无统计学差异。A组总转阴率为68.8%(22/32),B组为65.6%(21/32),差异无统计学意义;C组总转阴率为90.6%(29/32)。A组总有效率为78.1%(25/32),B组为75.0%(24/32),差异无统计学意义;C组总有效率为96.9%(31/32),高于A组与B组,差异均有统计学意义。结论:尤靖安联合膦甲酸钠治疗HPV感染可发挥全面抗病毒作用,并增强药物活性、强化抗HPV感染的疗效,较之单纯尤靖安及单纯膦甲酸钠治疗效果明显更佳。
OBJECTIVE: To compare the clinical efficacy of the combination of jingjingan, foscarnet sodium and the two in the treatment of HPV infection and explore the ideal clinical treatment for HPV infection. METHODS: A total of 96 HPV-infected patients admitted from January 2014 to August 2016 in our hospital were selected as study subjects. All the patients were divided into A, B and C groups according to a random number table, with 32 cases in each group. Group A was treated with Jing Jingan (recombinant human interferon α2b gel), while group B was treated with sodium phosphate sodium fosfonate alone. Group C was treated with combination of Jingufen and sodium foscarnet sodium chloride. Cervical inflammation index score, HPV negative conversion rate and total effective rate were compared between the three groups before and after treatment. Results: There was no significant difference between the three groups in the scores of cervicitis before treatment. The scores of cervicitis in groups A, B and C decreased to (2.5 ± 0.6) and (2.7 ± 0.7) (1.1 ± 0.4) points, with statistical significance before treatment; at the same time, the score of C group was lower than that of A group and B group; there was no significant difference between A group and B group. In group A, the total negative conversion rate was 68.8% (22/32) in group B, and 65.6% (21/32) in group B, with no significant difference. The total negative conversion rate in group C was 90.6% (29/32). The total effective rate in group A was 78.1% (25/32), in group B was 75.0% (24/32), the difference was not statistically significant. The total effective rate in group C was 96.9% (31/32) Group B, the differences were statistically significant. Conclusion: You Jingan combined with sodium foscarnet in the treatment of HPV infection can play a full antiviral effect, and enhance the activity of drugs to enhance the anti-HPV infection, compared with simple Jing Jing and simple foscarnet treatment effect was significantly better.