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目的：分析曲马朵用于产科镇痛后血浆β＿Ｅｎｄ和Ａｒｇ的变化。方法：初产妇２４例，年龄（２７±ｓ７）ａ，体重（６６±９）ｋｇ，孕周（３９．０±１．４）ｗｋ，潜伏期、活跃期和第２产程各８名。口服曲马朵１００ｍｇ镇痛。镇痛前后分别取前臂静脉血，分离血浆后按放射免疫分析法测定β＿Ｅｎｄ和Ａｒｇ的含量。结果：治疗后β＿Ｅｎｄ含量在潜伏期组为（９６±３９）ｎｇ／Ｌ、活跃期组为（１３２±６６）ｎｇ／Ｌ、第２产程组为（１９３±７３）ｎｇ／Ｌ。Ａｒｇ的含量分别为（３９±２１）ｎｇ／Ｌ，（６８±３３）ｎｇ／Ｌ，（７１±３１）ｎｇ／Ｌ。结论：β＿Ｅｎｄ含量在潜伏期、活跃期，第２产程组镇痛后较镇痛前明显下降；Ａｒｇ的含量潜伏期和第２产程组镇痛后较镇痛前明显下降。
Objective: To analyze the changes of plasma β_End and Arg after tramadol for obstetric analgesia. Methods: 24 cases of primipara (27 ± s7) a, weight (66 ± 9) kg, gestational age (39.0 ± 1.4) wk, latent period, active stage and the second stage of labor were all included. Oral tramadol 100mg analgesic. Before and after analgesia were taken forearm venous blood, plasma were separated by radioimmunoassay determination of β_End and Arg content. Results: After treatment, β_End was (96 ± 39) ng / L in the latency group, (132 ± 66) ng / L in the active group and (193 ± 73) ng / L in the second stage of labor. Arg content was (39 ± 21) ng / L, (68 ± 33) ng / L and (71 ± 31) ng / L respectively. CONCLUSION: The content of β_End in latent phase and active phase in the second stage of labor is lower than that before analgesia in the second stage of labor. The latency of Arg and the incidence of Arrhythmia in the second stage of labor are lower than those before the analgesia.