1672年 Thomas Willis 首次记载重症肌无力症(以下简称 MG),迄今已有三百年历史。1960年 Simpson 和 Nastk 认为本病为自身免疫性疾病,直至血清中发现抗乙酰胆硷受体(AChR)抗体,以及制作 MG 实验模型等研究,对此才能确定,至今仍不到10年。本文根据作者所观察的病例,结合文献,综述有关MG 的临床表现、诊断、病因及治疗等的最近认识。 Thomas Willis first recorded in 1672 myasthenia gravis (hereinafter referred to as MG), so far, three hundred years of history. Simpson and Nastk in 1960 that the disease is an autoimmune disease, until the serum anti-acetylcholine receptor (AChR) antibody, and the production of MG experimental model studies, which can be determined, still less than 10 years. This article based on the cases observed by the author, combined with the literature review of the clinical manifestations of MG, diagnosis, etiology and treatment of recent understanding.