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目的系统观察多发腔隙性脑梗死（ＭＬＩ）不同时期脑血管功能的变化。方法依发病时间将８５例ＭＬＩ患者分成急性ＭＬＩ组及慢性ＭＬＩ组。同时选取年龄、性别及既往病史与前两组匹配的脑血管病危险因素组（ＣＶＤＲＦ）做对照。用脑血管血液动力学指标估价脑血管功能。结果与ＣＶＤＲＦ组相比，ＭＬＩ组脑循环显著异常。与ＭＬＩ急性组相比，慢性组脑循环有部分改善。ＭＬＩ组，甚至ＣＶＤＲＦ组，均出现脑血管弹性及自动调节功能下降。结论ＭＬＩ患者梗死急性期、慢性期及梗死之前均出现了脑血管功能的异常，前两期下降更明显。
Objective To observe the changes of cerebrovascular function at different stages of multiple lacunar infarction (MLI). Methods According to the onset time, 85 patients with MLI were divided into acute MLI group and chronic MLI group. At the same time select the age, gender and past medical history and the first two groups matching the risk factors for cerebrovascular disease group (CVDRF) as a control. Cerebrovascular hemodynamic assessment of cerebrovascular function. Results Cerebral circulation was significantly abnormal in MLI group compared with CVDRF group. Compared with the acute MLI group, the cerebral circulation in the chronic group was partially improved. MLI group, and even CVDRF group, there are cerebral vascular elasticity and decreased auto-regulatory function. Conclusions Cerebral vascular dysfunction occurred in both acute phase, chronic phase and infarction before MLI in patients with MLI. The decline in the first two phases was more obvious.