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以刺激大鼠坐骨神经作为伤害性刺激，记录丘脑束旁核（Pf）神经元的伤害性放电为指标，观察云芝糖肽（PSP）对这种伤害性反应的影响，并进行药理学分析。结果如下：1．PSP能明显抑制Pf神经元的伤害性放电（P＜0．05）。2．纳洛酮（1mg／kg）能翻转PSP对Pf神经元的伤害性放电的抑制。3．注射5-羟色胺（5－HT）合成抑制剂对氯苯丙氨酸（PCPA）后，PSP的抑制作用消失。以上结果说明了PSP的镇痛作用可能是通过阿片能神经元系统和5－HT能神经元系统的调制而起作用的。
In order to stimulate the sciatic nerve of rats as a noxious stimulus, the nociceptive discharge of parafascicular parafascicular nucleus (Pf) neurons was recorded as index to observe the effect of PSP on the nociceptive response and pharmacological analysis. The results are as follows: 1. PSP can significantly inhibit the noxious discharge of Pf neurons (P <0.05). 2. Naloxone (1 mg / kg) reversed the inhibition of nociceptive discharge of Pf neurons by PSP. 3. After injection of 5-HT (5-HT) inhibitor p-chlorophenylalanine (PCPA), the inhibition of PSP disappeared. The above results indicate that the analgesic effect of PSP may be mediated by the modulation of opioid and 5-HT neuronal systems.