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目的:探讨肝癌患者血清MMP-7和MMP-2水平联合预测预后的价值及其与肝癌浸润转移的关系。方法:选择原发性肝癌患者125例为观察组,30例同期良性肝脏疾病患者为对照组。检测两组血清MMP-7和MMP-2水平,分析观察组肝癌浸润程度、淋巴结转移情况、3年生存率以及血清MMP-7和MMP-2水平与肝癌浸润、转移及预后的关系。结果:观察组治疗前后的血清MMP-7和MMP-2水平均高于对照组。与治疗前比较,治疗后观察组血清MMP-7和MMP-2水平均降低(P<0.05)。观察组浸润超过包膜、出现淋巴结转移和死亡患者血清MMP-7和MMP-2水平均高于未浸润包膜、无淋巴结转移和存活患者(P<0.05)。观察组血清MMP-7和MMP-2水平与其浸润超过包膜率、淋巴结转移率和3年生存率均相关,且两者联合预测肝癌预后的价值良好。结论:肝癌患者血清MMP-7和MMP-2水平较高,且与肝癌浸润、转移及预后相关,MMP-7和MMP-2联合预测预后的价值良好,可用于肝癌浸润、转移及预后评估。
Objective: To investigate the value of serum MMP-7 and MMP-2 levels in predicting prognosis of patients with hepatocellular carcinoma (HCC) and their relationship with invasion and metastasis of HCC. Methods: 125 patients with primary liver cancer were selected as observation group and 30 patients with benign liver disease as control group. The levels of serum MMP-7 and MMP-2 in the two groups were detected. The infiltration, lymph node metastasis, 3-year survival rate, serum MMP-7 and MMP-2 levels in the observation group were compared with the infiltration, metastasis and prognosis of HCC. Results: The serum levels of MMP-7 and MMP-2 in the observation group before and after treatment were higher than those in the control group. Compared with those before treatment, the levels of serum MMP-7 and MMP-2 in the observation group decreased after treatment (P <0.05). The levels of serum MMP-7 and MMP-2 in infiltration in the observation group were higher than those in the non-infiltrating capsule, lymph node metastasis and survival in patients with lymph node metastasis and death (P <0.05). The serum levels of MMP-7 and MMP-2 in the observation group were correlated with the infiltration rate, the rate of lymph node metastasis and the 3-year survival rate, and the combination of them both had a good value in predicting the prognosis of HCC. Conclusion: The serum levels of MMP-7 and MMP-2 in patients with hepatocellular carcinoma are high, and are correlated with the infiltration, metastasis and prognosis of hepatocellular carcinoma. The combination of MMP-7 and MMP-2 is of good prognostic value and can be used to evaluate the infiltration, metastasis and prognosis of hepatocellular carcinoma.