鼻内滥用可卡因有许多并发症,其中最常见的是鼻中隔穿孔,此外尚有鼻窦鼻道骨软骨坏死,类似We-gener’s肉芽肿的鼻中隔坏死和硬腭穿孔。可卡因粉末或晶体用力吸入所致的机械性破坏及伴随的血管收缩作用导致鼻中隔受损,这样长期的鼻内滥用引起结痂、出血和中隔穿孔。鼻内组织氧分压的降低有利于厌氧 Nasal misuse of cocaine has many complications, the most common of which is perforation of the nasal septum. In addition there is necrosis of the sinonasal sinus cartilage, nasal septal necrosis and palatal perforation, similar to Wegener’s granulomatosis. Mechanical seizures and consequent vasoconstriction caused by cocaine powder or crystalline inhalation cause nasal septal damage such that long-term intranasal abuse causes scarring, bleeding and septal perforation. Reduction of oxygen partial pressure in the nasal tissue is conducive to anaerobic