肺炎球菌多糖(PPS)对健康成人具有免疫原性和保护作用,而对幼儿则无这些作用,但将PPS与蛋白载体结合可明显增加其免疫原性和保护作用。特异性母体抗体虽可保护子代免受感染,但也能干扰子代对疫苗的免疫应答。曾报道,用PPS-破伤风蛋白结合疫苗(Pnc-TT)免疫母体能保护子代免受3种 Pneumococcal polysaccharide (PPS) has immunogenicity and protective effect on healthy adults, but no effect on young children, but the combination of PPS and protein carrier can obviously increase its immunogenicity and protective effect. Although specific maternal antibodies protect offspring from infection, they also interfere with the offspring’s immune response to the vaccine. It has been reported that immunization of mothers with PPS-tetanus protein conjugate vaccine (Pnc-TT) protects offspring from 3