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１９８９年Ｂｒｕｎｅｔｔｏｅｔａｌ［１］和Ｃａｒｍａｎｅｔａｌ［２］先后报道抗Ｈｂｅ阳性的慢性肝炎患者中，发现了ＨＢＶ前Ｃ区突变株，即在前Ｃ区１８９６点ＴＧＧ转变为ＴＡＧ，产生终止码，阻止ＨＢｅＡｇ合成．后来在许多国家和地区都相继发现了相同的突变株．在
1989 Brunetto et al [1] and Carmanetal [2] have reported anti- HBe-positive chronic hepatitis patients and found that pre-HBV mutated C region, that is, in the pre-C region 1896 TGG converted to TAG, produce stop codon, prevent HBeAg synthesis. Later in many countries and regions have found the same mutant strains. in