本文报道了分别用表达 2型单纯疱疹病毒 ( HSV- 2 )全长 g D或截短 g D( Δg D)的质粒p CDNAg D或 p CDNAΔ g D通过不同途径免疫小鼠 ,比较其诱导的体液和细胞免疫应答 ,并证明与粒细胞 -巨噬细胞集落刺激因子(GM- CSF)基因表达盒共同接种可增强HSV DNA疫苗的保护作用。　　每 Here we report that mice were immunized by different routes with plasmids pCDNAg D or pCDNA [Delta] g that express full-length gD or truncated gD (Ag) of herpes simplex virus type 2 (HSV-2), respectively, Humoral and cellular immune responses and demonstrated that co-immunization with the GM-CSF gene expression cassette enhances the protective effect of the HSV DNA vaccine. Each