黄毒素(Methoxsalen)是一与紫外线合用治疗特发性白斑病的药物。通常是将黄毒素制成硬胶囊供临床使用。由于黄毒素水溶性较差故其生物利用度很低。本文研究目的是寻找一个简单且灵敏的血药浓度测定方法以及研制一能迅速且有效吸收的药物制型,俾使病人服药后最适度地暴露于紫外线下,同时显著减少毒性药物的剂量。 Methoxsalen is a UV treatment for idiopathic vitiligo. Hard toxins are usually made into hard capsules for clinical use. Due to its poor water solubility, the bioavailability of the yellow toxin is very low. The purpose of this study was to find a simple and sensitive method for determination of plasma concentration and to develop a rapid and effective drug delivery system that would allow patients to receive the most appropriate exposure to UV light after taking their medication while significantly reducing the dose of toxic drugs.