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目的了解甘肃省当前艾滋病抗病毒治疗人群中艾滋病病毒(HIV)耐药株的流行状况,为甘肃省有效开展艾滋病抗病毒治疗提供依据。方法采用横断面调查方法,对甘肃省某机构初始抗病毒治疗9-15个月的43例成人病人进行访谈和采集血样,检测免疫学指标(CD4+T淋巴细胞)、病毒载量(VL)和耐药性指标(基因型突变)。对病毒载量≥1000拷贝/mL的血样进行耐药基因型检测。结果调查的43例病人,男性93.0%(40例)、汉族93.0%(40例)、大专及以上文化程度39.5%(17例)、城镇户口65.1%(28例)、同性性传播46.5%(20例)。3例病毒抑制失败,其中2例出现耐药,治疗人群中的耐药率为4.7%(2例),所有耐药病人均同时对核苷类及非核苷类反转录酶抑制剂耐药,没有病人对蛋白酶抑制剂耐药。耐药病人服药依从性良好。结论甘肃省抗病毒治疗人群中已经出现耐药现象,治疗失败病人主要是因为发生耐药,应加强开展规范合理的抗病毒治疗,及时进行耐药监测以预防耐药株的传播和流行。
Objective To understand the prevalence of HIV-resistant strains among HIV-infected people in Gansu province and provide the basis for effective anti-HIV treatment in Gansu province. Methods A total of 43 adult patients aged 9-15 months in an antiviral treatment of an institution in Gansu Province were interviewed and blood samples were collected for the detection of immunological indicators (CD4 + T lymphocytes), viral load (VL) And drug resistance (genotype mutation). Blood samples with a viral load> 1000 copies / mL were tested for drug resistance. Results Among the 43 patients surveyed, 93.0% (40 cases) were males, 93.0% (40 cases) Han nationality, 39.5% (17 cases) with college degree or above, 65.1% (28 cases) with urban hukou and 46.5% 20 cases). Three patients failed to respond to the virus, two of them showed resistance, and the resistance rate in the treatment group was 4.7% (two patients). All resistant patients were resistant to both nucleoside and non-nucleoside reverse transcriptase inhibitors No patient is resistant to protease inhibitors. Drug-resistant patients with good compliance. Conclusions The drug resistance phenomenon has emerged in the anti-virus treatment population in Gansu Province. The patients who failed the treatment mainly because of the occurrence of drug resistance, should conduct standardized and reasonable antiviral treatment and promptly conduct drug resistance surveillance to prevent the spread and prevalence of drug-resistant strains.