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采用免疫组织化学方法研究了６８例胃癌中癌细胞ｐ５３和ｐ２１基因蛋白表达与癌细胞侵袭力的关系。结果表明：６８例胃癌中有３６例ｐ５３基因蛋白染色阳性（５２．９％），４８例ｐ２１基因蛋白染色阳性（７０．６％）；浸润于浆膜层和肌层的癌细胞ｐ５３蛋白染色的阳性程度明显高于粘膜层癌细胞（Ｐ＜０．０５）；浸润性生长的癌细胞中ｐ５３和ｐ２１蛋白阳性程度均明显强于膨胀性生长的癌细胞（Ｐ＜０．０５）；淋巴结转移病例的癌细胞其ｐ５３和ｐ２１蛋白染色阳性率（分别为５４．３％和７３．９％）与无淋巴结转移的病例（分别为５０．０％和６３．６％）无显著性差异（Ｐ＞０．０５）；有淋巴结转移的病例中，原发癌ｐ５３蛋白阳性强度与转移癌正相关（γ＝０．６８，Ｐ＜０．０１）。结果提示：ｐ５３和ｐ２１基因蛋白染色阳性程度较高的胃癌细胞具有较强的侵袭力。
Immunohistochemistry was used to study the relationship between the expression of p53 and p21 gene protein and the invasiveness of cancer cells in 68 cases of gastric cancer. The results showed that: Of the 68 cases of gastric cancer, 36 cases were positive for p53 protein (52.9%), 48 cases were positive for p21 protein (70.6%); p53 protein staining in cancer cells infiltrating into the serosa and muscle layers. The positive degree was significantly higher than that of mucosal cancer cells (P<0.05); the positive degree of p53 and p21 protein expression in infiltrating cancer cells was significantly stronger than that of swollen growth cancer cells (P<0.05); The positive rates of p53 and p21 protein staining (54.3% and 73.9%, respectively) in metastatic cases were not significantly different from those without lymph node metastases (50.0% and 63.6%, respectively). P>0.05); In cases with lymph node metastasis, the positive intensity of p53 protein in primary cancer was positively correlated with metastatic cancer (γ=0.68, P<0.01). The results suggest that gastric cancer cells with higher positive staining of p53 and p21 genes have stronger invasiveness.