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目的探讨丙基硫氧嘧啶联合藿朴夏苓汤治疗甲状腺功能亢进症疗效及对其血清总三碘甲腺原氨酸(TT3)、促甲状腺素(TSH)水平的影响,为改善临床疗效提供参考。方法选取南阳市中心医院收治的87例甲状腺功能亢进症患者,随机分组,对照组43例口服50 mg丙基硫氧嘧啶治疗,观察组44例于对照组基础上加服藿朴夏苓汤治疗,均治疗2个月,观察比较两组临床疗效及血清TT3、TSH水平。结果观察组治疗总有效率为95.45%(42/44),高于对照组76.74%(33/43),差异有统计学意义(P<0.05);治疗后,观察组血清TT3水平低于对照组,血清TSH水平高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为9.09%(4/44),对照组为6.98%(3/43),差异无统计学意义(P>0.05)。结论藿朴夏苓汤与丙基硫氧嘧啶联合治疗甲状腺功能亢进症效果显著,安全性高,可改善患者血清TT3、TSH水平。
Objective To investigate the effect of propylthiouracil combined with Huopu Chaoling Decoction in treating hyperthyroidism and its effect on serum total triiodothyronine (TT3) and thyroid stimulating hormone (TSH), so as to provide reference for improving clinical efficacy. Methods 87 cases of hyperthyroidism admitted in Nanyang Central Hospital were randomly divided into control group (43 cases) treated with 50 mg propylthiouracil and control group (44 cases) After 2 months of treatment, the clinical efficacy and the levels of serum TT3 and TSH in the two groups were observed and compared. Results The total effective rate in the observation group was 95.45% (42/44), which was significantly higher than that in the control group (76.74%, 33/43) (P <0.05). After treatment, the TT3 level in the observation group was lower than that in the control group (P <0.05). The incidence of adverse reactions was 9.09% (4/44) in the observation group and 6.98% (3/43) in the control group, with no statistical difference Significance (P> 0.05). Conclusions The combination of huapu shuling soup and propylthiouracil is effective in treating hyperthyroidism, which is safe and can improve the levels of serum TT3 and TSH in patients.