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目的探讨毛细支气管炎患儿血清25-(OH)-D3水平、尿LTE4水平变化的临床意义及维生素D3干预对尿LTE4的影响。方法选择毛细支气管炎急性期患儿76例作为毛细支气管炎组,另选取同期在我院儿童保健门诊体检的60例健康儿童作为对照组。毛细支气管炎组患儿给予常规治疗,进入恢复期后,随机分为维生素D3干预组和未干预组,每组各38例,干预组予维生素D3滴剂400IU/天口服,未干预组不予处理,随访6个月。分别于入院次日(急性期)、维生素D3干预前一日(恢复期)检测各组患儿血清25-(OH)-D3和尿LTE4水平,并干预6个月后检测干预组及未干预组尿LTE4水平。结果毛细支气管炎重型及轻型患儿血清25-(OH)-D3水平均明显低于对照组;而尿LTE4则明显高于对照组;重型患儿血清25-(OH)-D3水平明显低于轻型患儿,尿LTE4水平明显高于轻型(P<0.05);急性期及恢复期血清25-(OH)-D3水平均低于对照组,尿LTE4水平明显高于对照组;急性期25-(OH)-D3水平明显低于恢复期;尿LTE4水平则明显高于恢复期(P均<0.01)。血清25-(OH)-D3与毛细支气管炎病情轻重呈负相关(r=-0.68,P<0.01),尿LTE4与病情轻重呈正相关(r=0.76,P<0.01);血清25-(OH)-D3与尿LTE4呈负相关(r=-0.63,P<0.05)。干预后,干预组及未干预组尿LTE4水平比较,两组之间差异无统计学意义(P>0.05)。结论毛细支气管炎患儿急性期维生素D3干预对尿LTE4无下调作用。
Objective To investigate the clinical significance of serum 25- (OH) -D3 level and urine LTE4 level in children with bronchiolitis and the effect of vitamin D3 intervention on urinary LTE4. Methods Sixty-six children with bronchiolitis were selected as bronchiolitis group in the acute stage. Sixty healthy children in the same period were selected as control group. Patients with bronchiolitis were given routine treatment. After entering the recovery period, they were randomly divided into vitamin D3 intervention group and non-intervention group, 38 cases in each group. The intervention group received 400 IU / day of vitamin D3 drops orally, Treatment, followed up for 6 months. Serum levels of 25- (OH) -D3 and urinary LTE4 in each group were detected on the next day after admission (acute phase) and on the day before vitamin D3 intervention (convalescence), and intervention group and intervention group Group urine LTE4 level. Results Serum levels of 25- (OH) -D3 in children with severe bronchiolitis were significantly lower than those in control group, while urine LTE4 was significantly higher than those in control group. Serum levels of 25- (OH) -D3 in children with severe bronchiolitis were significantly lower than those in control group Compared with control group, the levels of LTE4 in urine were significantly higher in light children than those in control group (P <0.05). The levels of serum 25- (OH) -D3 in acute and convalescent patients were lower than those in control group (OH) -D3 levels were significantly lower than recovery; urinary LTE4 levels were significantly higher than recovery (P all <0.01). Serum 25- (OH) -D3 was negatively correlated with severity of bronchiolitis (r = -0.68, P <0.01), and urine LTE4 was positively correlated with severity of disease (r = 0.76, ) -D3 was negatively correlated with urinary LTE4 (r = -0.63, P <0.05). After intervention, the levels of urinary LTE4 in intervention group and non-intervention group had no statistical significance (P> 0.05). Conclusions Vitamin D3 intervention in children with bronchiolitis in acute stage has no effect on the expression of LTE4.