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目的:观察疏血通注射液与前列地尔注射液联合使用治疗慢性肾脏病的疗效。方法:将94例慢性肾脏病患者随机分为3组,即治疗组、疏血通对照组和前列地尔对照组。治疗组32例,给予疏血通注射液和前列地尔注射液治疗;疏血通对照组31例,单纯给予疏血通注射液治疗;前列地尔对照组31例,单独给予前列地尔注射液治疗。14 d为1个疗程,1个疗程后观察患者血肌酐、尿素氮、尿蛋白定量和内生肌酐清除率的变化。结果:3组均可降低患者血肌酐、尿素氮、尿蛋白定量和内生肌酐清除率,但治疗组指标变化更显著(P<0.05)。结论:疏血通注射液与前列地尔注射液联合使用治疗慢性肾脏病具有叠加效应,临床疗效显著,值得进一步推广应用。
Objective: To observe the efficacy of Shuxuetong injection and alprostadil injection in the treatment of chronic kidney disease. Methods: Ninety-four chronic kidney disease patients were randomly divided into three groups: treatment group, Shuxuetong control group and alprostadil control group. In the treatment group, 32 cases were treated with Shuxuetong injection and alprostadil injection. Shuxuetong control group (n = 31) was treated with Shuxuetong injection only. In the alprostadil control group, 31 cases were treated with prostaglandin injection Liquid treatment. 14 d for a course of treatment, after a course of treatment observed in patients with serum creatinine, urea nitrogen, urine protein and endogenous creatinine clearance rate changes. Results: Serum creatinine, urea nitrogen, urinary protein and endogenous creatinine were all decreased in all three groups, but the indexes in the treatment group changed more significantly (P <0.05). Conclusion: Shuxuetong injection and alprostadil injection combined treatment of chronic kidney disease has a superposition effect, clinical efficacy is significant, it is worth further promotion and application.