在制取鼠疫菌菌苗时,减少培养基的耗量,降低制剂的费用,确保在培养基容量单位内细菌有较高的产量是至关重要的。因此,培养鼠疫菌病原体通常是在它们适宜生长的温度,即28℃条件下进行。但是,人们发现有些鼠疫菌抗原(包括透析性抗原)合成的高峰是在37℃。因此,用我们制取的三种培养基培养的鼠疫菌病原体培养物的免疫原性是很值得重视的。这三 In the preparation of Yersinia pestis vaccines, it is crucial to reduce the consumption of media, reduce the cost of preparation, and ensure that bacteria have higher yields in medium capacity units. Therefore, the cultivation of Yersinia pestis pathogens is usually carried out at a temperature at which they are suitable for growth, that is, at 28C. However, it was found that some of the Yersinia pestis antigens (including dialysis antigens) peaked at 37 ° C. Therefore, the immunogenicity of the Yersinia pestis cultures grown on the three media we prepared is of great importance. These three