弥散性血管内凝血(DIC)可能是急性白血病易出血的主要因素,其病理过程是异常的原始细胞释放前凝血质,进而血管内凝血酶形成,化疗引起大量瘤细胞溶解,更能加剧这一过程。尽管临床上急性白血病发生血栓栓塞仅占1％～2％,但尸检约有15％～25％病人可见弥漫性纤维蛋白流积。本文采用前瞻性随机的试验研究,观察硫酸皮肤素(dermatansulphate)与肝素对急性白血病合并DIC的治疗效果。 Disseminated intravascular coagulation (DIC) may be the main cause of acute leukemia bleeding. The pathological process is abnormal pro-coagulant pre-clotting, which leads to the formation of intravascular thrombin. Chemotherapy causes a large number of neoplastic cells to dissolve, which can further exacerbate this. process. Although clinically acute thromboembolism occurs in only 1% to 2% of patients with acute leukemia, diffuse fibrin accumulation is seen in approximately 15% to 25% of autopsy patients. This article uses a prospective randomized experimental study to observe the effect of dermatan sulfate (dermatansulphate) and heparin on the treatment of acute leukemia with DIC.