论文部分内容阅读
在15只戊巴比妥钠麻醉的开胸狗身上观察高渗溶液对血流动力学的影响,主要结果如下:1.静脉内注射50%葡萄糖溶液(3m1/kg,15s 内注毕),规律地引起心动徐缓、动脉血压降低、左心室(-dp/dt)减小、左心室+dp/dt 和心输出量增加,以及肾和股薄肌的血流阻力降低。25%甘露醇溶液具有类似作用。2.切断两侧颈迷走神经后,注射高渗溶液不再能诱发动脉低血压以及肾和股薄肌血流阻力的反射性降低,提示此类效应的传入通路主要为迷走神经。3.在切断迷走神经后注射高渗溶液,还使左心室+dp/dt 进一步增加,表明高渗溶液增强心肌收缩性。根据以上结果似可认为,静脉注射高渗溶液所致动脉血压降低,实质上反映着心输出量的增加不足以抵销外周阻力的减小。
The effects of hypertonic solution on hemodynamics were observed in 15 open-chest dogs anesthetized with sodium pentobarbital. The main results were as follows: 1. Intravenous injection of 50% glucose solution (3 ml / kg, within 15 s) Regularly causes bradycardia, decreased arterial pressure, decreased left ventricular (-dp / dt), increased left ventricular + dp / dt and cardiac output, and decreased resistance to flow in the kidney and gracilis. 25% mannitol solution has a similar effect. 2. Cut off the vagus nerve on both sides, the injection of hypertonic solution can no longer induce arterial hypotension and renal and gracilis reflex decreased blood flow resistance, suggesting that these effects of the afferent pathway is mainly the vagus nerve. 3. Injection of hypertonic solution after the vagus nerve was cut further increased left ventricular + dp / dt, indicating that hypertonic solution enhances myocardial contractility. Based on the above results seem to be that the intravenous infusion of hypertonic solution-induced arterial blood pressure decreased, in essence, reflects the increase in cardiac output is not enough to offset the reduction in peripheral resistance.