目的探讨妊娠期妇女在不同孕期暴露于环境香烟烟雾对妊娠结局的影响。方法符合纳入标准并愿意接受被动吸烟问卷调查的单胎孕妇734例,按被动吸入烟雾时间分为研究组(平均每天被动吸入吸烟者吐出的烟雾15 min)413例和对照组(平均每天被动吸入吸烟者吐出的烟雾低于15 min)321例。采用自填式和开放问询式问卷调查,内容包括孕妇一般情况及孕期不同时段被动吸烟情况等,跟踪随访其妊娠结局,分析孕妇不同时期被动吸烟对妊娠结局影响程度。结果研究组不同孕期早产儿、死胎(死产)、低出生体重儿、新生儿窒息、胎儿畸形5种不良妊娠结局发生率均明显高于非被动吸烟的对照组,且孕早期组与整个孕期组不良妊娠结局发生率亦明显高于孕中期、孕晚期组,组间比较差异有统计学意义(P<0.05),研究组孕妇唾液硫氰酸盐(SCN)含量和静脉血、尿及脐带血可替宁含量测定值均明显高于对照组,组间比较差异具有统计学意义(P<0.05)。结论孕妇不同孕期被动吸烟均会对自身和胎儿造成危害,增加其不良妊娠结局发生率,及早进行有效干预是妊娠期妇女避免暴露于环境香烟烟雾,减少不良妊娠结局发生的关键。 Objective To investigate the effect of pregnant women exposed to environmental cigarette smoke during pregnancy on pregnancy outcome. Methods A total of 734 singleton pregnant women who met the inclusion criteria and were willing to accept the passive smoking questionnaire were divided into study group (passive smoker smoked 15 min every day) and passive smoker (413 smokers per day) Smokers spit out the smoke less than 15 min) 321 cases. Using self-contained and open questionnaire survey, including the general situation of pregnant women and passive smoking during different periods of pregnancy, follow-up of their pregnancy outcomes, analysis of pregnant women at different periods of passive smoking on the impact of pregnancy outcomes. Results The incidence of 5 adverse pregnancy outcomes in preterm, stillborn (stillbirth), low birth weight, neonatal asphyxia and fetal malformation in the study group were significantly higher than those in the non-passive smoking control group, The incidence of adverse pregnancy outcomes was also significantly higher than that in the second trimester and the third trimester group (P <0.05). In the study group, the salivary thiocyanate (SCN) content, blood, urine and umbilical cord The measured values ​​of cotinine were significantly higher than the control group, the difference between the groups was statistically significant (P <0.05). Conclusions Passive smoking in pregnant women during pregnancy can cause harm to themselves and their fetus, increase the incidence of adverse pregnancy outcomes, and early effective intervention is the key to prevent pregnant women from exposure to environmental cigarette smoke and reducing the incidence of adverse pregnancy outcomes.