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目的进一步评价国产帕米膦酸二钠对肿瘤骨转移所致骨痛和高血钙的治疗作用，并观察该药的不良反应。方法４２例有溶骨性骨转移病灶的晚期肿瘤病人，接受５９个疗程帕米膦酸二钠（９０ｍｇ／ｄ，共用１天；或３０ｍｇ／ｄ，共用３天）治疗。结果帕米膦酸二钠对癌性骨痛的有效率为７１．２％，活动能力改善率为６７．３％；血钙升高者４例，经治疗后其血钙水平均降至正常；用药过程中均未见严重不良反应。结论帕米膦酸二钠是一种治疗恶性肿瘤骨转移引起的骨痛和高血钙的有效药物，病人耐受良好
Objective To further evaluate the therapeutic effect of domestic pamidronate disodium on bone pain and hypercalcemia caused by bone metastases, and observe the adverse reactions of the drug. Methods Forty-two patients with advanced bone metastases with osteolytic bone metastasis received 59 cycles of pamidronate disodium (90 mg/day for 1 day or 30 mg/day for 3 days). Results The effective rate of pamidronate disodium on cancerous bone pain was 71.2%, and the improvement rate of activity was 67.3%; 4 cases with elevated blood calcium, and the blood calcium level decreased to normal after treatment. No serious adverse reactions were seen in the course of medication. Conclusion Pamidronate disodium is an effective drug for the treatment of bone metastasis-induced bone pain and hypercalcemia in patients with malignant tumors. The patient is well tolerated.