肾功衰竭保守期的药物疗法下田益弘等引起肾小球损伤的因素可包括具有生物活性的物质的沉着、肾小球内、外凝血系统的功能亢进、系膜基质的蓄积、构成肾小球的各种细胞和来自血流中炎性细胞的生长因子或炎性物质的出现、代谢异常（糖尿病、高脂血症等）、肾小球超滤过或肾... Pharmacological therapy during conservative period of renal failure Shimoda Masahiro and other factors that cause glomerular damage may include the deposition of biologically active substances, hyperthyroidism of the glomerular and extra-clotting systems, accumulation of mesangial matrix, formation of glomeruli Of the various cells and inflammatory cells from the bloodstream in the presence of growth factors or inflammatory substances, metabolic abnormalities (diabetes, hyperlipidemia, etc.), glomerular ultrafiltration or renal ...