目的探讨临产孕妇凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)指标的变化及临床意义。方法采用普利森CA-2000A全自动血凝分析仪对285例临产孕妇(临产孕妇组)与150例健康体检者(对照组)凝血四项进行检测并作统计分析。结果临产孕妇组PT、APTT、TT、FIB分别为(12.77±2.37)s、(31.07±10.26)s、(11.67±3.48)s、(3.74±1.05)g/L;对照组PT、APTT、TT、FIB分别为(12.95±1.48)s、(30.85±6.52)s、(12.73±1.32)s、(2.80±0.51)g/L;临产孕妇组与对照组PT、APTT比较,差异无统计学意义(P>0.05),TT、FIB比较,差异有统计学意义(P<0.05)。结论临产前进行凝血四项检测对预防产妇异常出血、血栓、弥散性血管内凝血(DIC)有重要的临床参考价值。 Objective To investigate the changes and clinical significance of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB) in pregnant women. Methods Pulixen CA-2000A automatic hemagglutination analyzer was used to detect and make statistical analysis on the clotting of 285 pregnant women (parturient pregnant women group) and 150 healthy people (control group). Results The PT, APTT, TT and FIB in the pregnant group were (12.77 ± 2.37) s and (31.07 ± 10.26) s and (11.67 ± 3.48) s and (3.74 ± 1.05) g / (12.95 ± 1.62) s, (12.73 ± 1.32) s and (2.80 ± 0.51) g / L respectively in the pregnant women and non-pregnant women, and there was no significant difference in PT and APTT between the pregnant women and the control group (P> 0.05), TT, FIB, the difference was statistically significant (P <0.05). Conclusion Prenatal coagulation test four to prevent maternal abnormal bleeding, thrombosis, disseminated intravascular coagulation (DIC) has important clinical reference value.