新生儿持续性肺动脉高压(persistent pulmonary hypertension of the newborn,PPHN)是胎儿从宫内生活过渡到宫外生活期间,肺动脉压力及肺血管阻力持续升高导致血液经过卵圆孔和(或)动脉导管的右向左分流,临床表现为严重紫绀、进行性低氧血症的严重新生儿疾病。最新研究报道PPHN发病率为2/1 000活产婴儿,病死率为11.6%[1]。临床研究[2]和Meta分析[3]证实吸入一氧化氮(inhaled Persistent pulmonary hypertension of the newborn (PPHN) is a continuous increase in pulmonary artery pressure and pulmonary vascular resistance during fetal transition from intrauterine life to extrauteroral life, resulting in blood passing through the foramen ovale and / or arterial duct Right to left shunt, the clinical manifestations of severe cyanosis, progressive hypoxemia in severe neonatal disease. The latest study reported a PPHN incidence of 2/1 000 live births with a case fatality rate of 11.6% [1]. Clinical studies [2] and Meta analysis [3] confirmed inhalation of nitric oxide (inhaled