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目的探讨利福喷丁联合左氧氟沙星治疗初治菌阳肺结核患者的临床疗效。方法 82例初治菌阳肺结核的患者随机分为对照组和治疗组,每组41例。对照组患者单纯应用利福喷丁实施治疗;治疗组患者采用利福喷丁与左氧氟沙星联合实施治疗。结果治疗组患者肺结核病情控制总有效率90.2%明显高于对照组;痰菌检测结果完全转阴时间和用药治疗总时间(7.41±1.55)d、(12.9±2.43)d明显短于对照组(11.73±3.48)d、(17.95±4.14)d;两组用药期间没有出现药物不良反应。结论应用利福喷丁与左氧氟沙星联合对初治菌阳肺结核疾病的患者实施治疗的临床效果非常明显。
Objective To investigate the clinical efficacy of rifapentine combined with levofloxacin in treating patients with newly diagnosed bacillary positive pulmonary tuberculosis. Methods 82 cases of newly diagnosed bacillary positive pulmonary tuberculosis patients were randomly divided into control group and treatment group, 41 cases in each group. Patients in the control group were treated with rifapentine only. Patients in the treatment group were treated with rifapentine in combination with levofloxacin. Results The total effective rate of tuberculosis control in the treatment group was 90.2%, which was significantly higher than that of the control group (P <0.05). The time of complete negative conversion of sputum test and the total time of treatment (7.41 ± 1.55) d, (12.9 ± 2.43) d were significantly shorter than those of the control group 11.73 ± 3.48) d, (17.95 ± 4.14) d. No adverse drug reactions occurred during the two groups. Conclusion The application of rifapentine in combination with levofloxacin in treating patients with newly diagnosed bacillary positive pulmonary tuberculosis is of obvious clinical effect.