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目的探讨慢性阻塞性肺病(Chronic obstructive pulmonary disease,COPD)患者并发胃炎、胃溃疡及其幽门螺杆菌感染的关系。方法以因上消化道症状接受胃镜检查的COPD患者65例为实验组,紧随其后接受胃镜检查的65例其他患者为对照组,均在胃镜检查时钳取幽门口附近胃粘膜2～3块进行快速尿素酶检测,将所得结果进行统计分析。结果实验组检出慢性胃炎65例,溃疡病18例(占27.69%),幽门螺杆菌(HP)阳性22例(阳性率33.84%);对照组检出慢性胃炎65例,溃疡病5例(占7.69%),HP阳性38例(阳性率58.46%)。两组检出胃炎例数完全一致;两组溃疡病发病占比率差异有显著性;两组合并HP感染阳性率经统计学检验,差异有显著性(P<0.05)。结论COPD病人消化性溃疡发病率明显高于其他患者,而HP感染率明显低于其它患者,提示HP感染可能并非COPD患者出现上消化道症状以及消化性溃疡的主要原因,积极治疗原发病,改善通气等综合治疗才是缓解上消化道症状的主要手段。
Objective To investigate the relationship between gastritis, gastric ulcer and Helicobacter pylori infection in patients with chronic obstructive pulmonary disease (COPD). Methods Sixty-five COPD patients who underwent gastroscopy due to upper gastrointestinal symptoms were selected as the experimental group, followed by 65 patients undergoing gastroscopy for the control group. All patients underwent gastroscopy for grading 2 ~ 3 Block for rapid urease test, the results were statistically analyzed. Results There were 65 cases of chronic gastritis, 18 cases of ulcer (27.69%) and 22 cases of Helicobacter pylori (positive rate of 33.84%) in experimental group. 65 cases of chronic gastritis and 5 cases of ulcer Accounting for 7.69%), HP positive 38 cases (positive rate 58.46%). The two groups of gastritis detected exactly the same number of cases; two groups of ulcer disease incidence accounted for significant differences; two groups of HP infection positive rate by the statistical test, the difference was significant (P <0.05). Conclusions The incidence of peptic ulcer in patients with COPD is significantly higher than that of other patients, while the HP infection rate is significantly lower than other patients, suggesting that HP infection may not be the main cause of upper gastrointestinal symptoms and peptic ulcer in COPD patients. Active treatment of primary disease, Improve the ventilation and other comprehensive treatment is the main means to alleviate the symptoms of upper gastrointestinal tract.