抗凝血杀鼠剂长期使用后会产生抗药性。湛江地区从 70年代开始试用第一代抗凝血杀鼠剂 ,80年代推广使用 ,1988～1992年黄胸鼠抗药性达到 2 .41%～ 14 %〔1-3〕。为掌握近几年湛江地区鼠类抗药性发生程度 ,1999年 10～ 12月对湛江市和雷州市的黄胸鼠和褐家鼠进行抗凝血杀鼠剂的 Anticoagulant rodenticides will produce long-term use of drug resistance. Since the 1970s, Zhanjiang has tried the first generation of anticoagulant rodenticides and promoted it in the 1980s. From 1988 to 1992, the drug resistance of Radix toratosus reached 2.41% to 14% [1-3]. In order to grasp the extent of the occurrence of rodent resistance in Zhanjiang in recent years, from October to December 1999, Rattus flavipectus and Rattus norvegicus in Zhanjiang and Leizhou were treated with anticoagulant rodenticides