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切除修复在原核和真核细胞中都是修复DNA损伤的一种重要的方式,它在很大程度上保证了遗传信息的准确传递。有6种蛋白参与了原核细胞的切除修复过程,有关基因已被分离。克隆真核细胞切除修复基因也取得令人瞩目进展。一些辐射敏感的遗传性疾病常伴有切除修复功能的缺陷。转录活性对切除修复的影响引起了人们的极大兴趣。
Resection and repair in both prokaryotic and eukaryotic cells repair DNA damage is an important way, it largely to ensure the accurate transmission of genetic information. There are six proteins involved in the excision and repair of prokaryotic cells, the relevant genes have been isolated. Cloning eukaryotic excision repair gene also made remarkable progress. Some radiation-sensitive hereditary diseases are often accompanied by defects in resection and repair functions. The impact of transcriptional activity on excision repair has aroused great interest.