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本文介绍了一种LRH拮抗物〔D-多聚甘氨酸、 D-苯丙氨酸~2、D-色氨酸~(3、6)-LRH(〔D-pGlu~1、D-phe、D-Trp~(3、6)〕-LRH,以下简称拮抗物)的生物学效应,描述其对雌性大鼠妊娠的影响。用未生育过的雌性大鼠(体重230～250克)与雄性大鼠合笼后,以阴道涂片中出现精子算作妊娠的第一天。从妊娠的第一至第七天,每日上午9时或上午9时及下午5时两次,皮下注射溶于玉米油的该拮抗物,对照组注射等量玉米油。将大鼠分为4个不同的剂量组。前三组的剂量分别是:一组:
This article describes a class of LRH antagonists [D-polyglycine, D-phenylalanine ~ 2, D-tryptophan ~ (3,6) -LRH -Trp ~ (3,6)] - LRH, hereinafter referred to as antagonist), to describe its effect on pregnancy in female rats. Sperm was counted as the first day of gestation in vaginal smears with a female rat (weight 230-250 g) who had not been born. The antagonist was dissolved in corn oil subcutaneously from the first to the seventh day of pregnancy, at 9 a.m. or at 9 a.m. and 5 p.m., and the control group was injected with the same amount of corn oil. Rats were divided into 4 different dose groups. The first three groups of doses are: a group: